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Gastrointestinal effects of GLP-1 receptor agonists: mechanisms, management, and future directions - The Lancet Gastroenterology & Hepatology

Losing muscle around your hips, knees, spine, and shoulders leaves those areas more vulnerable to instability and mechanical overload, increasing the risk for: Tendinopathies Low back pain Knee osteoarthritis Rotator cuff injuries 2

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Most protocols run 8 to 12 weeks at a time